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MHC I and II proteins differences

Difference between MHC Class I and MHC Class II proteins
Major histocompatibility complex (MHC) or Human Leukocyte Antigen (HLA)complex consists of genes encoding cell surface glycoproteins that are required for antigen presentation to T cells and also responsible for rapid graft rejection.The acceptance or rejection of transplant is controlled by a set of genes in the recipient’s body which is called as Major histocompatibility complex (MHC) or Human Leukocyte Antigen (HLA) complex in humans. 

MHC Class I and MHC Class II proteins

MHC class I proteins
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MHC class I
MHC class II proteins
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MHC class II
1 Present on the surface of all nucleated cells Present on the surface of antigen presenting cells such as macrophages, B cells, dendritic cells etc.
2 Mainly interact with cytotoxic T cells Mainly interact with helper T cells
3 Encoded by HLA-A, HLA-B and HLA-C genes Encoded by HLA-D genes.
4 Consists of 2 non identical chains, a long alpha chain and a short beta chain Consists of 2 roughly identical chains, an alpha chain and a beta chain
5 Alpha chain is coded on MHC locus of chromosome 6, whereas beta chain is encoded on chromosome 15. Both chains are coded on MHC locus of chromosome 6
6 Responsible for graft rejection and clearance of endogenous antigens Responsible for graft rejection and clearance of exogenous antigens

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