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Nucleic acid Inhibitors

DNA Rifamycin:
  • The antibiotic interferes with prokaryotic RNA polymerase and thus, interferes with transcription. Blocks RNA synthesis by binding to and inhibiting RNA polymerase.
Fluoroquinolones :
  • inhibit DNA gyrase, a bacterial enzyme that unwinds DNA in preparation for replication and transcription. Both of these disruptions prevent bacteria from dividing to make more bacteria.
  • Inhibits DNA gyrase; interferes with DNA replication.

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