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ICMR JRF Exam Biochemistry Questions and Answers

1. Chaperon proteins:
icmr jrf exam
a) all require ATP to exert their effect
b) cleave incorrect disulphide bonds, allowing correct one to subsequently form
c) of the hso70 class are involved in transport of proteins across mitochondrial and endoplasmic reticulum membranes
d) guide the folding of polypeptide chains into patters that would be thermodynamically unstable without the presence of chaperons

2. G quadruplex DNA :
a) is stacked structure of guanine tetramers
b) is stabilized by metal cations
c) can form  either parallel or antiparallel arrangements
d) all of the above


3.The A helix of DNA differ from the B helix in the following except:
a) appearance of major and minor grove
b) pitch of the base pairs relative to the helix axis
c) tilt of the bases
d) polarity of the strands

4. Which of the following stimulates protein kinase A?
a) Insulin
b) Vasopressin
c) Oxytocin
d) Gonadotropin releasing hormone

5. A research technician who is working with ororganophosphate compounds is required to have a weekly blood test for
a) AST activity
b) LDH activity
c) ALT activity
d) Acetylcholine esterase activity

6. Which of the following is not involved in enzyme regulation?
a) suicide inhibition
b) covalent modification
c) competitive inhibition
d) allosteric activation

7. Which of the following is a serine protease
a) Ribonuclease
b)  Glutathione peroxidase
c) Acetyl choline esterase
d) Aspartate aminotransferase

8.Ribonuclease  P is
a) a kinase
b)a self splicing intron
c) an abzyme
d) a ribozyme

9. Abzymes are :
a) Catalytic antibodies
b) artificial enzymes
c) both and b
d) none of these

10.Gycosaminoglycans :
a) are the carbohydrate portion of glycoproteins
b) always contain sulphate
c)  are the carbohydrate portion of glycoproteins
d) contain large segments of repeating unit typically consisting of a hexosamine and a uronic acid

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Answers:
1.  c) of the hso70 class are involved in transport of proteins across mitochondrial and endoplasmic reticulum membranes
2. d) all of the above
3. d) polarity of the strands
4. b) Vasopressin
5. d) Acetylcholine esterase activity
6. a) suicide inhibition
7. c) Acetyl choline esterase
8. c) both and b
9. c) both and b
10. d) contain large segments of repeating unit typically consisting of a hexosamine and a uronic acid

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