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CSIR Life sciences Cancer and Cell Signaling Questions (Unit 4- Cell Communication and Cell Signaling)

Questions on Cancer Biology (Oncology)
1. The mutation in an oncogene falls under which of the following classes? (CSIR Life sciences,June 2016)
 1. Loss of function mutation
 2. Frame shift mutation
 3. Gain of function mutation
 4. Dominant negative mutation
 Ans:  3. Gain of function mutation
2. Which one of the following best defines an oncogene? (CSIR Life sciences,June 2016)
1. An oncogene never codes for a cell cycle protein, which promotes cell proliferation.
2. Oncogenes are always involved in inherited forms of cancer.
3. An oncogene codes for a protein that prevents a cell from undergoing apoptosis.
4. An oncogene is a dominantly expressed mutated gene that renders a cell advantageous towards survival. 
Ans: 4. An oncogene is a dominantly expressed mutated gene that renders a cell advantageous towards survival. 
3. Which of the following events will NOT usually lead to transformation of a normal cell into a cancer cell? (CSIR Life sciences,June 2016)
1. Gain of function of oncogenes
2. Loss of function of tumor suppressors
3. Gain of function of genes involved in nucleotide excision repair
4. Loss of function of pro-apoptosis related Genes
Ans: 3. Gain of function of genes involved in nucleotide excision repair
 CSIR Life sciences Cancer and Cell Signalling Questions (Unit 4 - Cell Communication and Cell Signaling)
Questions on Cell signaling
4. Which one of the following statements about receptor – enzyme is FALSE? (CSIR Life sciences,June 2016)
1. A receptor – enzyme has an extracellular ligand binding domain, a transmembrane domain and an intracellular catalytic (enzyme) domain.
2. Many types of receptor enzymes are found in animals.
3. The signal transduction pathways of receptor – enzyme involve phosphorylation cascades.
4. Receptor – enzymes interact directly with  intracellular G-proteins.
Ans: 4. Receptor – enzymes interact directly with  intracellular G-proteins.

5. In the above signalling cascade, which one of the following molecules is denoted by ‘B’? (CSIR Life sciences,June 2016)

1. STAT 5
2. SMAD 6
3. GSK3
4. SMAD 4
Ans: 4. SMAD 4
6. Cell to cell communication is important in development of an organism. The ability of cells to respond to a specific inductive signal is called (CSIR Life sciences,June 2016)
1. Regional specificity of induction
2. Competence
3. Juxtracrine signalling
4. Instructive interaction
Ans: 2. Competence

7. Which of the following is NOT a second messenger? (CSIR Life sciences,Dec 2015)
 1. Cyclic GMP
 2. Diacylglycerol
 3. Inositol triphosphate
 4. Phosphatidyl inositol

Ans: 4. Phosphatidyl inositol
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