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Difference between Gene replacement therapy and Corrective gene therapy

Gene replacement therapy vs Corrective gene therapy

No
Gene replacement therapy
(Gene augmentation)
Corrective gene therapy

1

Addition of healthy gene without replacing defective gene

Addition of healthy gene replacing defective gene.


2

Suitable for recessive disorders

Possible for dominant disorders.


3

Non-specific insertion and no recombination event

Site specific insertion and recombination event should occur.


4

Approach is not useful when the defective gene produces a disease causing protein

Approach is useful when the defective gene produces a disease causing protein or an interfering substances.


5

The approach is more feasible

Extensive study is required.


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