Lists of Anticancer DrugsAnticancer Drugs or Antineoplastic AgentsDefinition: Anticancer, or antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy.Common Anticancer Drugs
No
|
Name
|
Type
|
Mode of action
|
1
|
Folic acid Analogue
|
Competitive inhibitor of
dihydrofolate reductase. THFA is required for nucleotide synthesis
|
|
2
|
Mitomycin C
|
Antibiotics
|
Cross bridges are formed between DNA base pairs
|
3
|
Actinomycin D
|
Antibiotics
|
Intercalates with guanine bases of DNA; prevents transcription.
|
4
|
Cis platin
|
Platinum compound
|
Forms intrastrand DNA adducts
|
5
|
Etoposide
|
Podophyllotoxin
|
Stabilises isomerase II DNA cleavage complexes
|
6
|
Campotothecin
|
Modifies function of topoisomerases I to DNA breaking agent
|
|
7
|
Vincristine
&
Vin blastine
|
Alkaloids from Vinca rosea
|
Interfers with assembly of cytoskeleton and inhibits spindle movement
(stathmokinesis)
|
8
|
Adriamycin
|
Anthracyclines
|
Topo isomerase mediated breaks in DNA
|
9
|
Cyclophosphamide
|
Alkylating agent
|
Cross linking of bases of DNA ; inhibition of strand separation
|
10
|
6 Mercapto purine
|
Purine Analogue
|
Inhibits the conversion of IMP
to AMP
|
11
|
6 thioguanine
|
Purine Analogue
|
Inhibits thymidylate synthase reaction
|