List of anticancer drugs and its molecular mechanisms of action

Anticancer Drugs or Antineoplastic Agents

Definition: Anticancer, or antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy.

Common Anticancer Drugs

 Lists of Anticancer Drugs 

No	Name	Type	Mode of action
1	Methotrexate	Folic acid Analogue	Competitive inhibitor of dihydrofolate reductase. THFA is required for nucleotide synthesis
2	Mitomycin C	Antibiotics	Cross bridges are formed between DNA base pairs
3	Actinomycin D	Antibiotics	Intercalates with guanine bases of DNA; prevents transcription.
4	Cis platin	Platinum compound	Forms intrastrand DNA adducts
5	Etoposide	Podophyllotoxin	Stabilises isomerase II DNA cleavage complexes
6	Campotothecin		Modifies function of topoisomerases I to DNA breaking agent
7	Vincristine &  Vin blastine	Alkaloids from Vinca rosea	Interfers with assembly of cytoskeleton and inhibits spindle movement (stathmokinesis)
8	Adriamycin	Anthracyclines	Topo isomerase mediated breaks in DNA
9	Cyclophosphamide	Alkylating agent	Cross linking of bases of DNA ; inhibition of strand separation
10	6 Mercapto purine	Purine Analogue	Inhibits  the conversion of IMP to AMP
11	6 thioguanine	Purine Analogue	Inhibits thymidylate synthase reaction

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