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List of anticancer drugs and its molecular mechanisms of action

Anticancer Drugs or Antineoplastic Agents
Definition: Anticancer, or antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy.
Common Anticancer Drugs

mode of action of anticancer drugs
 Lists of Anticancer Drugs 


No
Name
Type
Mode of action
1


Folic acid Analogue
 Competitive inhibitor of dihydrofolate reductase. THFA is required for nucleotide synthesis
2
Mitomycin C
Antibiotics
Cross bridges are formed between DNA base pairs
3
Actinomycin D
Antibiotics
Intercalates with guanine bases of DNA; prevents transcription.
4
Cis platin
Platinum compound
Forms intrastrand DNA adducts
5
Etoposide
Podophyllotoxin
Stabilises isomerase II DNA cleavage complexes
6
Campotothecin

Modifies function of topoisomerases I to DNA breaking agent
7
Vincristine
&
 Vin blastine
Alkaloids from Vinca rosea
Interfers with assembly of cytoskeleton and inhibits spindle movement (stathmokinesis)
8
Adriamycin
Anthracyclines
Topo isomerase mediated breaks in DNA
9
Cyclophosphamide
Alkylating agent
Cross linking of bases of DNA ; inhibition of strand separation
10
6 Mercapto purine
Purine Analogue
Inhibits  the conversion of IMP to AMP
11
6 thioguanine
Purine Analogue
Inhibits thymidylate synthase reaction





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