Apoptotic pathway is activated upon failure of DNA repair mechanisms to correct DNA damage. In this pathway, p53 on activation induces expression of BAX gene or Apaf-1 gene. The BAX gene product induces cell to undergo apoptosis or programmed cell death.
After more than 30 years of research in this gene, now it is very clear that p53 inactivation is essential for the onset of all types of cancers.
- p53 : The Most Frequently Altered Gene in Human Cancers. Nature Education 3(9):6
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- Haupt, Y., Maya, R., et al. Mdm2 promotes the rapid degradation of p53. Nature 387, 296–299 (1997).