Comparison of B and T cells involved in Immune Response (B cells vs Tcells)

Lymphocytes are mononucleate, nongranular leukocytes of lymphoid tissue, participating in immunity. They are found in blood, lymph and lymphoid  tissues such as spleen, lymph nodes, tonsils, Peyer’s patches, appendix. etc. The lymphocytes are of two types. They are B lymphocytes and T lymphocytes.
Comparison of B and T cells:
B cellsB cell
T cellsT cell
Origin Bone marrow in adults Bone marrow in adults
Maturation Lymphoid tissue or bone marrow; Bursa of Fabricius in birds Thymus
Longevity Short (Few days to a week) Long (Months to years)
Complement receptors Present Absent
Surface immunoglobulins Present Absent
Proliferation Proliferate upon antigenic stimulation, differentiate into plasma and memory cells Proliferate upon antigenic stimulation
Type of immunity Humoral immunity Cell mediated and humoral
Secretary product Antibodies Lymphokines
Distribution High in spleen, lymph nodes, bone marrow and other lymphoid tissues, Low in blood High in blood, lymph and lymphoid tissue
Types and Functions
  • Memory cells- along lived cell responsible for the anamnestic response.
  • Plasma cell- a cell arising from a B cell that manufactures specific antibodies
  •  Tc Cell- Lysis cells recognised as non self and parasite infected cells.
  • TH cell- It is necessary for B cell activation by T-dependent antigens and T effector cell.
  • T regulator cell- It develops into TH or Ts cells and control balance between enhancement and suppression of response to antigen.
  • Ts cell: It blocks induction  and or/ activation of TH cells and B cells. It helps maintain tolerance.
  • TDTH cell: It provides protection against infectious agents, mediates inflammation and activates macrophages in delayed type hypersensitivity
  • Null cells- Lymphocytes that lacks surface cell markers
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