Immunology Practice Test on Antibodies or Immunoglobulins

Immunoglobulins or specific antibodies or gamma globulins are blood proteins, which are found to be defensive only against the specific microorganisms, or their toxins that evoked that particular antibody. Immunoglobulins are glycoproteins, made up of 4 polypeptide chains (linked by disulphide bonds). There are two long chains, called heavy or H chains, and two short chains, called light or L chains. The four polypeptide chains are held together to form Y shaped molecule. The top two tips of this  shaped molecule bind to the specific antigens in a lock and key fashion, forming an antigen antibody complex.
1. Newborns
receive maternal B cells
respond to antigens as well as adults
have virtually a fully complement of maternal IgG antibodies
receive IgM antibodies from the mother through placental transfer
2. IgE
is bound together by J chain
is present in high concentration in serum
differs from IgG antibody because of its different H chains
bind to mast cells through its Fab region
3. IgA
is present in milk and saliva
is involved in hay fever
crosses the placenta
activates complement by the classical pathway
4. Human IgM
crosses the placenta
protects mucosal surfaces
is largely restricted to the circulation
is the antibody produced by high affinity plasma cells
5. Cells destined to become IgA producing plasma cells do not...
produce J chain
produce secretory component
migrate from mucosal areas on stimulation with antigen
home to any mucosal area
6. Immunoglobulin light chains
are joined chains by peptide bonds.
are present in the Fab fragment of IgG
all have the same amino acid composition.
are not found in every major immunoglobulin class
7. Ig heavy chains are
expressed by T cells
not important to binding of antigen
not glycosylated
encoded by a constant exon, variable exon, diversity exon and joining exon
8. The Fab portion of Ig
contains the J chain
binds to an Fc receptor
contains the idiotype of the Ig
mediates biological effector functions of Ab molecules
9. The Fc region of antibody
contains both heavy and light chains
is required for antigen binding
generally confers biological activity on the various molecules
is not a requirement for placetal transmission
10. Tears contain
all of the above
Score =
Correct answers:


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