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T cell receptor (TCR) Structure and Function

T cells has unique surface receptors which interacts specifically with an antigen. Helper T cell receptor can bind only to antigenic peptide MHC class II complex on antigen presenting cells. T helper cells activate both T cells and B cells.
T cell receptor
T cell receptor
  • TCR is a heterodimer consisting of alpha and beta chain
  • A variable region the hypervariable region determines the specificity
  • A constant region
  • A transmembrane region for anchorage
  • And a short cytoplasmic region that interacts with cytoskeletal structures
  • Each T cell bears a TCR of single specificity
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