1 Under alkaline conditions, DNA is more stable than RNA because
(A) RNA forms secondary structures
(B) RNA is a single stranded molecule
(C)RNA has uracil in place of thymidine
(D)RNA is susceptible to hydrolysis
2 Which one of the following modifications is common to both protein and DNA?
(A) SUMOylation
(B) Nitrosylation
(C) Methylation
(D) Ubiquitination
3 Protein A, which has strong affinity to Fc region of immunoglobulin, is extracted from (A)Saccharomyces cerevisiae
(B)Staphylococcus aureus (C)Streptococcus pyogenes
(D)Streptococcus sanguis
4 The first humanized monoclonal antibody approved for the treatment of breast cancer is (A) Rituximab
(B) Cetuximab
(C) Bevacizumab
(D) Herceptin
6 The role of an adjuvant is to (A) prolong the persistence of antigen
(B) cross link the antigen
(C) increase the size of antigen
(D) avoid inflammation
8 Human genome sequencing project involved the construction of genomic library in
(A)bacterial artificial chromosome
9 The nucleotide analogue used in DNA sequencing by chain termination method is
(A) 1',3'-dideoxy nucleoside triphosphate
(B) 2',3'-dideoxy nucleoside triphosphate
(C) 2',4'-dideoxy nucleoside triphosphate
(D) 2',5'-dideoxy nucleoside triphosphate
10 In nature, the horizontal gene transfer across bacteria is mediated by
(A) gene cloning followed by transformation
(A) RNA forms secondary structures
(B) RNA is a single stranded molecule
(C)RNA has uracil in place of thymidine
(D)RNA is susceptible to hydrolysis
2 Which one of the following modifications is common to both protein and DNA?
(A) SUMOylation
(B) Nitrosylation
(C) Methylation
(D) Ubiquitination
3 Protein A, which has strong affinity to Fc region of immunoglobulin, is extracted from (A)Saccharomyces cerevisiae
(B)Staphylococcus aureus (C)Streptococcus pyogenes
(D)Streptococcus sanguis
4 The first humanized monoclonal antibody approved for the treatment of breast cancer is (A) Rituximab
(B) Cetuximab
(C) Bevacizumab
(D) Herceptin
(B) Thr
(C) Pro
(D) Tyr
6 The role of an adjuvant is to (A) prolong the persistence of antigen
(B) cross link the antigen
(C) increase the size of antigen
(D) avoid inflammation
(B) MHC-I
(C) Fc γ receptor
(D) complement receptor
8 Human genome sequencing project involved the construction of genomic library in
(A)bacterial artificial chromosome
(B)pBR322
(C) bacteriophage
(C) bacteriophage
(D) pcDNA3.1
9 The nucleotide analogue used in DNA sequencing by chain termination method is
(A) 1',3'-dideoxy nucleoside triphosphate
(B) 2',3'-dideoxy nucleoside triphosphate
(C) 2',4'-dideoxy nucleoside triphosphate
(D) 2',5'-dideoxy nucleoside triphosphate
10 In nature, the horizontal gene transfer across bacteria is mediated by
(A) gene cloning followed by transformation
(B)conjugation and transformation
(C) conjugation only
(C) conjugation only
(D) transformation only
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Answers:
1. (D)RNA is susceptible to hydrolysis
Refer: Stability of DNA or RNA
2. (C)Methylation
3. (B)Staphylococcus aureus
4. (D) Herceptin
Herceptin/Herclon (Trastuzumab) is a monoclonal antibody that interferes with the HER2/neu receptor. Its main use is to treat certain breast cancers.
5. (C) Pro
6. (A) prolong the persistence of antigen
9. (B) 2',3'-dideoxy nucleoside triphosphate
